I am no expert, but have been reflecting on this of late.
Don't spray regular 2k topcoat at home without a booth. Use ISO free 2k topcoat at home if you like, but it's not as durable as regular 2k.
As far as 2k primers, I have used Spray Chief 2k primer which is an epoxy primer, needs no etch primer and works as high fill too to paint the zed 15 years ago. We were very happy with it. The owner of Spray Chief at the time was a family friend and he said it was ok to use without a booth, but he advised us that there 2k topcoats and clears were poisonous and to avoid without a booth.
If you have a good 2k base, a quality acrylic is ok but durability will be the biggest issue. Not a big deal if you have a garaged weekender. If you want extra durability use ISO free 2k topcoat at home or rent a booth and use regular 2k.
I am still deciding what to do. I want to paint the zed with doors, fenders and hatch off the car which makes it a bit of a PITA to get to a booth.
Either way with a good 2k base, even if you go acrylic you minimise shrinkage and stone chips to the metal and the extra work of using etch primer, spray putty and then re prime before topcoat.
No one should use single PAC acrylic primer anymore!