If the underlying idea is to make a 2+2 Z look like, or more like, a 2-seater Z, then the main issue is, obviously, the roof line. If the 2+2 roof was to be reshaped to the more flowing 2-seater roof shape then that obviously affects the side windows & panels, the rear hatch etc etc. Pretty major work. Option 1 - perhaps limited to a re-shape the car's roof & pillars, but retain the longer wheelbase of the 2+ 2; or go further yet with option 2 - shorten the wheelbase so to perhaps graft on 2-seater roof & rear panels & use 2-seater doors & side windows. Note that the 2+2 is slightly wider across the back end, adding a complication for 2-seater panel grafting.
Best to simply join the front end of a clean Z to the back end of a 2-seater Z & be done with it, should one have a couple of good shells laying around, as noted in a post above.
But nothing is impossible. There have been lots of modified cars over the years that look as if they could be factory products or factory prototypes. Take the 1960's-era after-market station wagon or shooting brake conversions of various cars like Mustangs & Zephyrs for instance - today they are highly collectible. And there are firms in the USA today who convert early Mustang hardtops into fastbacks or convertibles due to the preponderance of hardtops available (far more were built) & the far fewer sound rust-free fastbacks & convertibles.
Interesting topic & something that many & in particular 2+2 Z owners have no doubt pondered.